Is breast cancer hereditary?
Breast cancer occurs when cells in the breast grow abnormally and uncontrollably. In some cases, this aggressive cell growth is linked to inherited gene mutations. Hereditary breast cancer accounts for about 5% to 10% of all breast cancer cases.
Gene Mutations and Breast Cancer Risk
The most well-known gene mutations associated with breast cancer are BRCA1 and BRCA2. These genes normally help repair damaged DNA. However, when they are mutated, they can allow abnormal cells to grow and multiply unchecked.
People who inherit a BRCA1 or BRCA2 mutation may:
Have up to a 70% chance of developing breast cancer during their lifetime.
Be diagnosed with breast cancer at a young age.
Have a higher likelihood of developing cancer in both breasts.
Be at increased risk for other cancers, such as ovarian cancer.
Other gene mutations—such as PALB2, ATM, and CHEK2—have also been linked to an increased risk of breast cancer, though the risk may be lower than that associated with BRCA mutations.
It is also important to note that inheriting any of these genes does not guarantee that a person will develop cancer, but it does increase the risk.
The Role of Family History
Family history plays a big part in increasing one’s risk for breast cancer, as having a mother, sister, or daughter with this disease doubles a person’s risk. That number is even higher if that family member under the age of 50 was diagnosed or if there are many family members with the disease.
Some ethnic groups, such as those with Ashkenazi Jewish ancestry, are known to have an increased prevalence of gene mutations linked with breast cancer.
Know Your Risk–Take Action
Understanding your risk can lead to early detection and better outcomes. Steps you can take include:
Genetic testing for inherited mutations (If recommended by your healthcare provider).
Regular mammograms and other screenings.
Talking with your doctor about your family history and any concerns.
Schedule Your Mammogram Today
Knowledge is power—especially when it comes to your health. Take control by understanding your risk and staying proactive with routine screenings.
Call one of our radiology offices today to schedule your mammogram and take the first step toward protecting your health.